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  • Title: Effects of nicotine on gastric contractile response to stimulation of the vagal afferent fibers in cats.
    Author: Okamoto T, Kurahashi K, Fujiwara M, Okikawa H.
    Journal: Jpn J Pharmacol; 1989 Nov; 51(3):435-7. PubMed ID: 2622097.
    Abstract:
    Effects of nicotine on the delayed gastric contraction due to vagal afferent stimulation were studied. Cats were pretreated with phentolamine (2 mg/kg, i.v.) and propranolol (1 mg/kg, i.v.). The delayed contraction was inhibited by nicotine (100 to 2000 micrograms/kg, i.v.) in a dose-dependent manner. The inhibition of the delayed contraction by nicotine was blocked by hexamethonium (20 mg/kg, i.v.). The results suggested that nicotine inhibits the delayed contraction by activation of hexamethonium-sensitive inhibitory neurons in the vagal pathway to the stomach.
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