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  • Title: FTO Polymorphism rs9939609 Contributes to Weight Changes in Children With Celiac Disease on Gluten-Free Diet.
    Author: Grandone A, Marzuillo P, Cirillo G, Squitieri R, Tolone S, Miraglia del Giudice E, Perrone L, Tolone C.
    Journal: J Pediatr Gastroenterol Nutr; 2015 Aug; 61(2):220-3. PubMed ID: 26222659.
    Abstract:
    OBJECTIVES: Studies of adults and children with celiac disease have reported an increased risk of overweight during gluten-free diet (GFD). The fat mass and obesity-associated gene (FTO) variant rs9939609 has been associated with increased risk of developing obesity in children and adults. METHODS: In our study, we analyzed the effect of this variant on weight gain in a cohort of 280 children with celiac disease on GFD. RESULTS: We found that after a mean follow-up time of 3.0 years on GFD, FTO polymorphism influenced significantly the mean change in body mass index z score (P = 0.01). CONCLUSIONS: We conclude that the FTO gene contributes to determine weight changes in children with celiac disease on GFD.
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