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  • Title: High performance liquid chromatographic (HPLC) determination of centchroman in human serum and application to single-dose pharmacokinetics.
    Author: Paliwal JK, Gupta RC, Grover PK, Asthana OP, Srivastava JS, NityaNand S.
    Journal: Pharm Res; 1989 Dec; 6(12):1048-51. PubMed ID: 2622859.
    Abstract:
    A simple and sensitive (2 ng/ml) HPLC method with fluorescence detection has been developed to measure serum concentrations of centchroman, a new nonsteroidal antifertility agent. The method was sufficiently sensitive to follow the drug over 21 days in human volunteers. Pharmacokinetic parameters of centchroman were determined after a single oral dose of 60 mg (2 x 30-mg tablets) in two healthy female volunteers. Centchroman is slowly eliminated from serum, showing a biexponential disappearance curve from serum. The terminal half-life of centchroman in the two volunteers was 168 and 175 hr, respectively.
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