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  • Title: [The significance of an increased protein and fat content in the food ration of rats for the development of stable alloxan diabetes].
    Author: Ul'ianov AM, Tarasov IuA.
    Journal: Probl Endokrinol (Mosk); 1989; 35(6):78-81. PubMed ID: 2622891.
    Abstract:
    An effective model of stable and prolonged alloxan diabetes in rats was described. For this purpose the rats were kept on a synthetic diet with the increased level of proteins and lipids during 1-2 mos. before i.v. injection of alloxan at a dose of 35-40 mg/kg with subsequent feeding by this ration during all the time of the experiment. This model of experimental diabetes ensures a high level of hyperglycemia and hypoinsulinemia as well as a high titer of activity of the diabetogenic factor, to the same extent, as in rats kept on the common laboratory ration.
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