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  • Title: Treatment of chronic hepatitis delta virus (HDV) infection with human lymphoblastoid alpha interferon.
    Author: Farci P, Karayiannis P, Brook MG, Smedile A, Lai ME, Balestrieri A, Saldanha JA, Monjardino J, Gerin J, Thomas HC.
    Journal: Q J Med; 1989 Nov; 73(271):1045-54. PubMed ID: 2623137.
    Abstract:
    Ten patients with evidence of continuing HDV replication were treated with lymphoblastoid alpha-interferon and eight more were followed as a non-randomized control group. Four out of eight patients who completed one year of follow-up had cleared HDV-RNA from the serum whilst none of the control group did so. In these four responding cases there was a transient increase in transaminase levels during treatment and in two, this was followed by improvement. One patient also cleared HBV and seroconverted to anti-HBs (antibody to hepatitis B surface antigen--HBsAg). In one patient with sustained loss of HDV, recurrence of HDV infection was detected 18 months after completion of treatment. These data suggest that alpha-interferon can inhibit HDV replication in the short term but relapse after one to two years may occur. Inhibition of HDV-RNA is associated with improvement in the inflammatory liver disease and now larger studies are required to determine whether it influences survival.
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