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  • Title: A new biflavone glucoside from the roots of Stellera chamaejasme.
    Author: Chen W, Luo XH, Wang Z, Zhang YY, Liu LP, Wang HB.
    Journal: Chin J Nat Med; 2015 Jul; 13(7):550-3. PubMed ID: 26233846.
    Abstract:
    The present study investigated the chemical constituents of the roots of Stellera chamaejasme (Thymelaeaceae). One new biflavone glucoside (1), along with other thirteen known compounds (2-14), was isolated by repeated column chromatographic methods and their structures were elucidated on the basis of spectral analyses. The cytotoxic activities of selected compounds were evaluated against four human cancer cell lines (A549, BEL-7402, HCT-116, and MDA-MB-231) by the SRB assay method. Compound 9 showed remarkable cytotoxicity against BEL-7402 with IC50 value being 0.65 μg·mL(-1); compounds 7, 8, and 12 exhibited significant cytotoxic activity against A549 with IC50 values being 2.38, 1.57, and 2.35 μg·mL(-1), respectively.
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