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  • Title: STMN1 overexpression correlates with biological behavior in human cutaneous squamous cell carcinoma.
    Author: Li X, Wang L, Li T, You B, Shan Y, Shi S, Qian L, Cao X.
    Journal: Pathol Res Pract; 2015 Nov; 211(11):816-23. PubMed ID: 26235036.
    Abstract:
    Stathmin 1 (STMN1) is an important molecule in regulating cellular microtubule dynamics and promoting microtubule depolymerization in interphase and late mitosis. Evidences showed that STMN1 was up-regulated in many cancers, but there was no report about the roles of STMN1 in human cutaneous squamous cell carcinoma (cSCC). Here, we confirmed significant upregulation of STMN1 in cSCC tissues and cell lines compared with non-tumor counterparts. STMN1 upregulation was associated with the proliferation, migration, invasion and apoptosis of cSCC cells. The results suggested that STMN1 may play an important role in the development and tumor progression of cSCC.
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