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  • Title: The effects of brain edema on intracranial pressure in focal cerebral ischemia. An experimental study in a rat using magnetic resonance imaging.
    Author: Kotwica Z, Persson L, Thuomas KA.
    Journal: Zentralbl Neurochir; 1989; 50(2):68-71. PubMed ID: 2624022.
    Abstract:
    Intracranial pressure (ICP) changes and the development of cerebral edema during the first 24 hours after middle cerebral artery (MCA) occlusion in a rat were studied. ICP was measured via a catheter implanted into cisterna magna and the dynamics of cerebral edema was observed using serial T2 magnetic resonance (MR) measurements. Two T2 components were separated, fast (30-120 ms) and slow (120-240 ms). The first IPC increase was noted within first 2 hours after MCA occlusion and thereafter ICP started to rise 6 hours after stroke. These findings correlated with the development of edema, especially with the increase in extracellular water seen in T2 images. The highest ICP and the largest edema was noted in rats with largest infarcts. An experiment forms a basis for further studies on ICP and edema in a rat model of focal cerebral ischemia.
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