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  • Title: [The effect of pyrazidol and inkazan on the rotation behavior of rats].
    Author: Mashkovskiĭ MD, Bogdanov MB, Bondarenko NA.
    Journal: Farmakol Toksikol; 1989; 52(6):29-32. PubMed ID: 2625142.
    Abstract:
    Effect of some MAO inhibitors on rotational behavior induced by d-amphetamine in unilaterally 6-OHDA-lesioned rats was studied. Among all MAO inhibitors tested only 1-deprenyl induced rotational behavior. Nialamide, chlorgiline, pyrazidol and inkazan dose-dependently enhanced rotational behavior induced by 2 mg/kg i. p. d-amphetamine and pargiline depressed it. Nialamide and inkazan greatly enhanced rotational behavior induced by 0.5 mg/kg i. p. d-amphetamine. It is suggested that nialamide and inkazan may have similar effects on DA-ergic neurotransmission.
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