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  • Title: Novel antibacterial active quinolone-fluoroquinolone conjugates and 2D-QSAR studies.
    Author: Panda SS, Liaqat S, Girgis AS, Samir A, Hall CD, Katritzky AR.
    Journal: Bioorg Med Chem Lett; 2015 Sep 15; 25(18):3816-21. PubMed ID: 26253630.
    Abstract:
    Novel, quinolone-fluoroquinolone conjugates 10a-f, 11a-f, 13a-f and 14a-f with amino acid linkers were synthesized in good yields utilizing benzotriazole chemistry. Antibacterial bioassay showed the synthesized bis-conjugates exhibit anti-bacterial properties comparable with the parent drugs.
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