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  • Title: Genetics of Hearing Loss--Nonsyndromic.
    Author: Chang KW.
    Journal: Otolaryngol Clin North Am; 2015 Dec; 48(6):1063-72. PubMed ID: 26275501.
    Abstract:
    Eighty percent of nonsyndromic hearing losses are caused by autosomal-recessive (AR) inheritance, while most of the other 20% are caused by autosomal-dominant (AD) inheritance. Although AR nonsyndromic SNHL is most commonly caused by GJB2 and SLC26A4, there is no single gene that accounts for any significant proportion of AD SNHL. High-throughput sequencing techniques, also called next-generation sequencing (NGS) or massively parallel sequencing (MPS), may allow for routine definitive diagnosis of all possible genetic causes for hearing loss in the not-too-distant future.
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