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  • Title: Clinical efficacy of a bleaching enzyme-based toothpaste. A double-blind controlled clinical trial.
    Author: Llena C, Oteo C, Oteo J, Amengual J, Forner L.
    Journal: J Dent; 2016 Jan; 44():8-12. PubMed ID: 26275929.
    Abstract:
    OBJECTIVES: To assess the efficacy of a bleaching enzyme-based toothpaste. MATERIAL AND METHODS: A randomized clinical trial was carried out, comprising 48 participants with teeth exhibiting color A3 or higher according to the Vita Classical guide. One-half of the sample received the bleaching enzyme-based toothpaste (White Kin(®)), while the other received placebo toothpaste. Both products were supplied in identical containers and had the same composition except for the active components. The teeth color was measured with a spectrophotometer. The patients were instructed to brush their teeth three times a day during 3 min with the assigned product, during 12 weeks. The color measurements were repeated after 3, 6, 9 and 12 weeks of treatment. Color variation was based on the CIE L*a*b* coordinates, ΔE and the EW index. The relationship of these variables at different observation times were performed using a generalized estimating equations model, which evaluated the effect of treatment, time and interaction. RESULTS: The patients using the bleaching enzyme-based toothpaste showed an increase in lightness (80.14 -treatment- versus 79.25 -control group-) and a reduction in component b*. ΔE was found higher in the treatment group (p=0.064), close to statistical significance. CONCLUSIONS: The bleaching enzyme-based toothpaste could be potentially efficient in the modification in tooth color progressing from the third to ninth week of treatment, tending to stabilize after the ninth week. CLINICAL RELEVANCE: A very low carbamide peroxide concentration, with the incorporation of lactoperoxidase, tooth paste, tends to offer clinically satisfactory results, in terms of modifications in tooth color, nevertheless no significant differences were founded when compared to the control group, with an oral hygiene controlled along the study.
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