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  • Title: Carbon tetrachloride-induced experimental cirrhosis in the rat: a reappraisal of the model.
    Author: Ariosto F, Riggio O, Cantafora A, Colucci S, Gaudio E, Mechelli C, Merli M, Seri S, Capocaccia L.
    Journal: Eur Surg Res; 1989; 21(5):280-6. PubMed ID: 2627982.
    Abstract:
    The goal of this study was to evaluate the presence of extrahepatic damage and the uniformity and reversibility of the histological findings in CCl4-induced liver cirrhosis in the rat. To verify these findings rats were sacrificed 2 and 10 weeks after a treatment consisting of ten intragastric doses of CCl4, administered weekly. All treated rats developed an irreversible micronodular cirrhosis with no damage to the brain, kidney and pancreas. Moreover, rats sacrificed 2 weeks after the last CCl4 dose showed a number of functional alterations usually observed in man. In particular, low branched chain/aromatic amino acids (BCAA/AAA) plasma ratio, high ammonia, low zinc and high insulin with normal blood glucose were obtained.
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