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  • Title: Additive effect of Lygodium venustum SW. in association with gentamicin.
    Author: Morais-Braga MF, Souza TM, Santos KK, Guedes GM, Andrade JC, Tintino SR, Sobral-Souza CE, Costa JG, Saraiva AA, Coutinho HD.
    Journal: Nat Prod Res; 2016 Aug; 30(16):1851-3. PubMed ID: 26284428.
    Abstract:
    The aim of this work was to evaluate the interactions between gentamicin and the ethanol extract of the fern Lygodium venustum SW (EELV). The ethanol extract of L. venustum was obtained, the phytocompounds were identified and the EELV was assayed by the checkerboard method with gentamicin against two bacterial strains multiresistant to antibiotics. The antibiotic activity of gentamicin, when associated with the extract, was enhanced in an additive manner against both strains. The results indicated that L. venustum can be a source of secondary metabolites to be used in association with antibiotics as aminoglycosides in the antibiotic chemotherapy against resistant bacteria.
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