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Title: Presence of cholinergic neurons in the vagal afferent system: biochemical and immunohistochemical approaches. Author: Ternaux JP, Falempin M, Palouzier B, Chamoin MC, Portalier P. Journal: J Auton Nerv Syst; 1989 Dec; 28(3):233-42. PubMed ID: 2628466. Abstract: The presence of cholinergic fibers in the afferent vagal system of various species was shown using biochemical and immunohistochemical methods. Biochemical activity of choline acetyl transferase, the synthesizing enzyme for acetylcholine, was detected in the nodose ganglion of cat, rabbit, dog and sheep. Immunohistochemistry, using a monoclonal antibody raised against choline acetyl transferase, revealed labelled cell bodies in the nodose ganglion of the rabbit. Acetylcholine endogenous content, measured in nodose ganglia devoid of efferent fibers, was twice as high in the right ganglion as compared to the left. Enzyme transport and choline acetyl transferase activity analysis were each determined on separate peripheral vagus nerves. These results are discussed in terms of functional properties of the vagal afferent neurons, including the modulation of vagal afferent messages at the level of the nodose ganglion and the eventual control of peripheral intrinsic neurons by sensory vagal terminals.[Abstract] [Full Text] [Related] [New Search]