These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Methylazoxymethanol acetate (MAM ac) effects on the ontogenesis of the mouse neocortex.
    Author: Ciaroni S, Cecchini T, Gazzanelli G, Del Grande P.
    Journal: J Hirnforsch; 1989; 30(6):699-705. PubMed ID: 2628489.
    Abstract:
    Methylazoxymethanol acetate (MAM ac) injected prenatally affects development of neocortex in mice. Treatment at 13 days of gestation results in cortical hypoplasia that affects all the cortical layers except the first. Treatment at 15 days of gestation causes a statistically significant reduction in cell density in the superficial layers, while the deepest layers show no significant differences compared to the controls. Treatment at 17 days of gestation causes an alterated arrangement of the cortical layers, not easily separable since MAM ac in limiting perhaps glial cell proliferation, modifies the subsequent migration mechanisms. Fetal MAM exposure prevents proliferation of the various cortical laminae and there aren't subsequent compensatory phenomena.
    [Abstract] [Full Text] [Related] [New Search]