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  • Title: ITPRs/inositol 1,4,5-trisphosphate receptors in autophagy: From enemy to ally.
    Author: Decuypere JP, Parys JB, Bultynck G.
    Journal: Autophagy; 2015; 11(10):1944-8. PubMed ID: 26291777.
    Abstract:
    ITPRs (inositol 1,4,5-trisphosphate receptors), the main endoplasmic reticulum (ER) Ca(2+)-release channels, were originally proposed as suppressors of autophagy. Yet, new evidence has accumulated over recent years supporting a crucial, stimulatory role for ITPRs in driving the autophagic flux. Here, we provide an integrated view on how ITPR-mediated Ca(2+) signaling can have a dual impact on autophagy, depending on the characteristics of the spatio-temporal Ca(2+) signals, including the existence of ER-mitochondrial and ER-lysosomal Ca(2+) signaling microdomains.
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