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  • Title: [EXPERIMENTAL AND THEORETICAL STUDIES OF HUMAN HYPERCAPNIC VENTILATORY RESPONSE WITH THE USE OF MATHEMATICAL GAS EXCHANGE MODELING].
    Author: D'iachenko AI, Ermolaev ES, Shulagin YA, Goncharov AO, Suvorov AV.
    Journal: Aviakosm Ekolog Med; 2015; 49(3):38-43. PubMed ID: 26292424.
    Abstract:
    A mathematical model of biotechnical system integrating the human cardiorespiratory system with hard- and software was designed to investigate breathing control. The model describes dynamics of carbon dioxide and oxygen in 3 biotechnical system compartments in the course of rebreathing tests. The tests do not require tanks with compressed gas and, therefore, can be performed in space flights. Results of simulated modeling of the ventilation response in 2 breath tests, i.e. to hypercapnia due to rebreathing of a hyperoxic gas mixture and to hypercapnia combined with hypoxia due to air rebreathing, are presented. Model validity was verified by comparison of the modeling and experimental data. The mathematical model made it evident that CO2 partial pressures in tissues, lungs and the breathing circuit equalize very fast when initial carbon dioxide concentration in the respiration circuit is equal to the end-tidal CO2 concentrations in man at rest.
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