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  • Title: [Biometric research in the diagnosis of precancerous states and endocervical cancer].
    Author: Novik VI, Agroskin LS, Papaian GV, Solov'eva LV.
    Journal: Arkh Patol; 1989; 51(12):45-50. PubMed ID: 2629663.
    Abstract:
    Smears of the endocervical channel taken from 58 patients with various endocervical conditions (reserve cell hyperplasia and dysplasia, reserve cell carcinoma in situ. Adenocarcinoma in situ, invasive glandular and poorly differentiated carcinoma) were stained by Feulgen method. Morphometrical (surface, perimeter, maximum and minimum diameter) and light microscopic (mean optical density of staining, its dispersion, DNA content) parameters of the epithelial cell nuclei were measured by means of telemetric image analyzer. The most informative biometrical indexes are found, the role of the DNA cytophotometry in the differential diagnosis is determined, the algorithm of the automated cytomorphological diagnosis of the dysplasia and endocervical carcinoma is developed.
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