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  • Title: Investigating the Role of JAK/STAT Pathway on Dasatinib-Induced Apoptosis for CML Cell Model K562.
    Author: Dalgıç CT, Kaymaz BT, Özkan MC, Dalmızrak A, Şahin F, Saydam G.
    Journal: Clin Lymphoma Myeloma Leuk; 2015 Jun; 15 Suppl():S161-6. PubMed ID: 26297271.
    Abstract:
    We aimed to evaluate the cytotoxic and apoptotic effects of dasatinib (BMS-354825) on K562 chronic myeloid leukemia (CML) cells and to examine the roles of STAT genes on dasatinib-induced apoptosis. The results showed that dasatinib decreased proliferation and induced apoptosis in K562 cells in a dose- and time-dependent manner. mRNA and protein levels of STAT5A and STAT5B genes were significantly reduced in dasatinib-treated K562 cells. These data indicated that STAT inhibition by dasatinib might be therapeutic in JAK/STAT pathway-associated malignancies after confirmation with clinical studies.
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