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  • Title: [The diagnostic value of CT in siderophilia (primary idiopathic hemochromatosis)].
    Author: Klöppel R, Reinhardt M, Lieberenz S, Fuchs M, Winnefeld K, Machnik G.
    Journal: Gastroenterol J; 1989; 49(3):122-5. PubMed ID: 2629780.
    Abstract:
    CT, due to its high resolution of density, is suitable, within certain limits, to quantify iron contents in the liver. - Diagnostic value and limits of dual-energy-computed tomography after 38 examinations, 31 of them in patients with verified haemochromatosis, are described: In a progressive state of iron overload a high correlation exists between results of computed tomography and usual reference methods of iron metabolism (iron determination by absorption spectrometry and histologic examination, serum-iron-level, serum-ferritin-level, relative transferrin saturation, desferal test). - With a specificity of nearly 100% CT shows a minor or medium iron overload only with low sensitivity. - Because of its noninvasive nature CT is an alternative method of biopsy in progressive liver disease with suspected hepatic siderosis.
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