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  • Title: Renal LECT2 amyloidosis: a newly described disorder gaining greater recognition.
    Author: Kowalski A, Cabrera J, Nasr S, Lerma E.
    Journal: Clin Nephrol; 2015 Oct; 84(4):236-40. PubMed ID: 26308079.
    Abstract:
    Amyloidosis results from the pathologic deposition of beta pleated sheet fibrils within various organs including the kidney. Most often, the deposition is composed of the well-known monoclonal immunoglobulin light chains (AL) or serum amyloid A protein (AA). Recently, a new type of amyloidogenic protein was discovered, leukocyte chemotactic factor 2 (LECT2). This type of amyloid tends to have an affinity to kidney and liver and is recognized as a distinct clinico-pathologic type of amyloidosis, presenting with varying degrees of impaired kidney function and proteinuria. Herein, a case of this uncommon novel amyloidosis is presented with a brief review of the literature.
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