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  • Title: BIOPHYSICS. Comment on "Extreme electric fields power catalysis in the active site of ketosteroid isomerase".
    Author: Natarajan A, Yabukarski F, Lamba V, Schwans JP, Sunden F, Herschlag D.
    Journal: Science; 2015 Aug 28; 349(6251):936. PubMed ID: 26315426.
    Abstract:
    Fried et al. (Reports, 19 December 2014, p. 1510) demonstrated a strong correlation between reaction rate and the carbonyl stretching frequency of a product analog bound to ketosteroid isomerase oxyanion hole mutants and concluded that the active-site electric field provides 70% of catalysis. Alternative comparisons suggest a smaller contribution, relative to the corresponding solution reaction, and highlight the importance of atomic-level descriptions.
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