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  • Title: Verification by the FISH translocation assay of historic doses to Mayak workers from external gamma radiation.
    Author: Sotnik NV, Azizova TV, Darroudi F, Ainsbury EA, Moquet JE, Fomina J, Lloyd DC, Hone PA, Edwards AA.
    Journal: Radiat Environ Biophys; 2015 Nov; 54(4):445-51. PubMed ID: 26319788.
    Abstract:
    The aim of this study was to apply the fluorescence in situ hybridization (FISH) translocation assay in combination with chromosome painting of peripheral blood lymphocytes for retrospective biological dosimetry of Mayak nuclear power plant workers exposed chronically to external gamma radiation. These data were compared with physical dose estimates based on monitoring with badge dosimeters throughout each person's working life. Chromosome translocation yields for 94 workers of the Mayak production association were measured in three laboratories: Southern Urals Biophysics Institute, Leiden University Medical Center and the former Health Protection Agency of the UK (hereinafter Public Health England). The results of the study demonstrated that the FISH-based translocation assay in workers with prolonged (chronic) occupational gamma-ray exposure was a reliable biological dosimeter even many years after radiation exposure. Cytogenetic estimates of red bone marrow doses from external gamma rays were reasonably consistent with dose measurements based on film badge readings successfully validated in dosimetry system "Doses-2005" by FISH, within the bounds of the associated uncertainties.
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