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  • Title: Prevention of adverse effects of gamma-ray irradiation after metallothionein induction by bismuth subnitrate in mice.
    Author: Satoh M, Miura N, Naganuma A, Matsuzaki N, Kawamura E, Imura N.
    Journal: Eur J Cancer Clin Oncol; 1989 Dec; 25(12):1727-31. PubMed ID: 2632256.
    Abstract:
    The effect of preinduction of metallonthionein (MT) by bismuth subnitrate (BSN) on the adverse effects and antitumor activity of gamma-ray irradiation was investigated in mice. Preinduction of MT by oral administration of BSN significantly reduced the lethal effects and bone marrow injury caused by total body irradiation with gamma-rays. A significant increase in the MT concentration in bone marrow was observed in mice treated with BSN. In tumor-bearing mice, pretreatment with BSN did not compromise the antitumor activity of gamma-ray irradiation although bone marrow injury was remarkably suppressed. These results suggest that BSN pretreatment is an effective method for protection against side-effects in radiotherapy.
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