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  • Title: Functions of a GyrBA fusion protein and its interaction with QnrB and quinolones.
    Author: Chen C, Villet R, Jacoby GA, Hooper DC.
    Journal: Antimicrob Agents Chemother; 2015 Nov; 59(11):7124-7. PubMed ID: 26324265.
    Abstract:
    In order to study the interactions between Escherichia coli DNA gyrase and the gyrase interacting protein QnrB in vivo, we constructed a gyrB-gyrA fusion and validated its ability to correct the temperature-sensitive growth of gyrA and gyrB mutants. Like wild-type gyrA, the gyrB-gyrA fusion complemented a quinolone-resistant gyrA mutant to increase susceptibility. It functioned as an active type II topoisomerase, catalyzed negative supercoiling of DNA, was inhibited by quinolone, and was protected by QnrB.
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