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  • Title: Nickel-Catalyzed Reductive Coupling of Aryl Bromides with Tertiary Alkyl Halides.
    Author: Wang X, Wang S, Xue W, Gong H.
    Journal: J Am Chem Soc; 2015 Sep 16; 137(36):11562-5. PubMed ID: 26325479.
    Abstract:
    A mild Ni-catalyzed reductive arylation of tertiary alkyl halides with aryl bromides has been developed that delivers products bearing all-carbon quaternary centers in moderate to excellent yields with excellent functional group tolerance. Electron-deficient arenes are generally more effective in inhibiting alkyl isomerization. The reactions proceed successfully with pyridine or 4-(dimethylamino)pyridine, while imidazolium salts slightly enhance the coupling efficiency.
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