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  • Title: Activity of Daflon 500 mg on the hemorheological disorders in diabetes.
    Author: Lacombe C, Lelievre JC, Bucherer C, Grimaldi A.
    Journal: Int Angiol; 1989; 8(4 Suppl):45-8. PubMed ID: 2632648.
    Abstract:
    A rheological study was performed on blood samples from 10 insulin-treated diabetics with retinopathy. As part of their treatment, they all received 4 tablets of Daflon 500 mg per day for 30 days. Three complementary rheological criteria were used to characterize blood samples: 1) viscometry, using a Couette viscometer, which produces data on viscosity, shear-thinning, viscoelasticity and tixotropy of blood, 2) aggregametry, using an apparatus based on light reflectometry, using a filtrometer based on the deformations red cells undergo as they pass through narrow pores which produces information on red cell deformability. The main results were: a better red blood cell disaggregability, a decrease in red blood cell aggregation and no change in red blood cell deformability.
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