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  • Title: Effects of Cyclophosphamide Pulse Therapy on the Clinical and Histopathological Findings, Particularly Crescent Formation, in a Patient with Adult-onset Steroid-refractory Henoch-Schönlein Purpura Nephritis.
    Author: Tanaka Y, Nakashima Y, Mima T, Ohya M, Yamamoto S, Kobayashi S, Masumoto A, Masumoto K, Yano T, Moribata M, Yoshimoto W, Yamanaka S, Koreeda D, Hanba Y, Tatsuta K, Sakaguchi T, Negi S, Shigematsu T.
    Journal: Intern Med; 2015; 54(17):2207-11. PubMed ID: 26328648.
    Abstract:
    A 29-year-old woman was diagnosed with Henoch-Schönlein purpura nephritis (HSPN) based on the presence of purpura and histopathological findings showing crescent formation, mesangial proliferation and IgA deposition in the glomerular mesangium. She was treated with high-dose steroids; however, the nephritic syndrome persisted. Therefore, we diagnosed her with steroid-resistant HSPN and decided to add treatment with cyclosphamide pulse therapy. After one year of treatment, the histopathological findings, including crescent formation and IgA deposition, improved, as confirmed on a renal biopsy, and the patient fulfilled the criteria for complete remission. Cyclophosphamide pulse therapy may be considered an effective treatment for intractable HSPN.
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