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  • Title: New Anti-inflammatory Norcembranoids from the Soft Coral Sinularia numerosa.
    Author: Yin CT, Wen ZH, Lan YH, Chang YC, Wu YC, Sung PJ.
    Journal: Chem Pharm Bull (Tokyo); 2015; 63(9):752-6. PubMed ID: 26329871.
    Abstract:
    Two new norcembranoids, sinumerolide A (1) and its epimer, 7E-sinumerolide A (2), were isolated from the ethyl acetate extract of the soft coral Sinularia numerosa. The structures of compounds 1 and 2 were established using spectroscopic methods. In the in vitro anti-inflammatory effect test, norcembranoids 1 and 2 were found to inhibit the accumulation of the pro-inflammatory inducible nitric oxide synthase protein of lipopolysaccharide-stimulated RAW264.7 macrophage cells significantly.
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