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  • Title: neo-Clerodane Diterpenoids from Scutellaria barbata and Their Inhibitory Effects on LPS-Induced Nitric Oxide Production.
    Author: Yeon ET, Lee JW, Lee C, Jin Q, Jang H, Lee D, Ahn JS, Hong JT, Kim Y, Lee MK, Hwang BY.
    Journal: J Nat Prod; 2015 Sep 25; 78(9):2292-6. PubMed ID: 26331882.
    Abstract:
    Three new neo-clerodane diterpenoids (1-3) along with 12 known compounds (4-15) were isolated from a methanol extract of the aerial parts of Scutellaria barbata. The structures of 1-3 were determined by interpretation of their 1D and 2D NMR spectroscopic data as well as HRESIMS values. All isolated compounds were tested for their inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 macrophages. Compounds 1-4, 7, and 10-12 were found to inhibit nitric oxide production with IC50 values ranging from 20.2 to 35.6 μM.
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