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  • Title: [Activity of platelet serotonin receptors of patients with endogenous depression before and after treatment with antidepressive agents].
    Author: Katasonov AB, Beliaev BS, Brusov OS, Zlobina GP, Faktor MI.
    Journal: Zh Nevropatol Psikhiatr Im S S Korsakova; 1989; 89(12):75-8. PubMed ID: 2633575.
    Abstract:
    Effective 5-HT concentration eliciting the half-maximal rate of platelet deformation (aggregation) in drug-free bipolar or unipolar depressed women was significantly (p less than 0.001) lower as compared with matched controls (0.13 +/- 0.04 microM and 0.532 +/- 0.1 microM, respectively). After 1-3 months of antidepressant treatment this value increased to 0.47 +/- 0.16 microM and was no longer different from control. Possible mechanisms controlling the activity of serotonin2 platelet receptors are discussed.
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