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  • Title: Draft genome sequence of Streptomyces sp. TP-A0882 reveals putative butyrolactol biosynthetic pathway.
    Author: Komaki H, Ichikawa N, Hosoyama A, Fujita N, Igarashi Y.
    Journal: FEMS Microbiol Lett; 2015 Oct; 362(20):. PubMed ID: 26337155.
    Abstract:
    We report the draft genome sequence of marine-derived Streptomyces sp. TP-A0882, a producer of buryrolactol, an antifungal γ-lactone-containing polyketide. The genome harbored at least three type I polyketide synthase (PKS), three type II PKS, four nonribosomal peptide synthetase (NRPS) and two hybrid PKS/NRPS gene clusters. Annotation of gene functions enabled us to identify the type I PKS gene cluster for butyrolactol biosynthesis and propose a plausible biosynthetic pathway for this unique polyketide.
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