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  • Title: [ACTH's ectopic secretion in a patient with precedents of Cushing's disease].
    Author: Dal Verme A, Cejas C, Margan M, Siguelboim D, Canosa V, Peralta C.
    Journal: Medicina (B Aires); 2015; 75(4):218-20. PubMed ID: 26339876.
    Abstract:
    A 54-year-old man, with a history of Cushing's disease diagnosed 32 years earlier, presented with edema, asthenia and general malaise. Abnormal laboratory studies depicted hypokalemia and metabolic alkalosis. A CT scan of the chest revealed a 3×3 cm tumor in the anterior mediastinum. The pathology was consistent with a thymic carcinoid. These findings led to a diagnosis of biochemical Cushing's syndrome secondary to ectopic secretion of ACTH. Thus, this patient suffered twice of Cushing's syndrome. The first instance was the consequence of an ACTH--secreting pituitary adenoma and the second of an ectopic secretion of ACTH. To the best of our knowledge this is the first such case reported in the medical literature.
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