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  • Title: Heterogeneity of anion exchangers mediating chloride transport in the proximal tubule.
    Author: Aronson PS, Kuo SM.
    Journal: Ann N Y Acad Sci; 1989; 574():96-101. PubMed ID: 2634360.
    Abstract:
    Three distinct anion exchangers are described that directly or indirectly mediate Cl- transport across the luminal membrane of the proximal tubule cell. Studies on the intact proximal tubule indicate that the Cl(-)-formate exchanger is a major mechanism for Cl- transport under physiologic conditions. As just discussed, the physiologic importance of the Cl(-)-oxalate and SO4 = (oxalate)-CO3 = exchangers mediating Cl- transport across the luminal membrane of the proximal tubule cell is currently unknown. These three anion exchangers are part of a larger group of at least eight distinct anion transporters in the proximal tubule that share with erythrocyte Band 3 the properties of stilbene sensitivity and/or the ability to mediate anion exchange. It is tempting to speculate that these proximal tubule anion transporters are members of a family of proteins structurally related to the prototypic anion exchanger, erythrocyte Band 3. If this is true, comparing the structures of these anion transporters with each other and with Band 3 should provide important insight into the molecular basis for differences in substrate and inhibitor specificity within this family of transport proteins.
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