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  • Title: [The information value of clinico-hematologic criteria for the early diagnosis of acute radiation sickness in pig-tailed macaques].
    Author: Lapin BA, Vladimirov VG, Barkaia VS, Teslenko VM, Torua RA.
    Journal: Biull Eksp Biol Med; 1989 Dec; 108(12):676-8. PubMed ID: 2634438.
    Abstract:
    Ten pig-tailed monkeys (Macaca nemestrina) were subjected to 60Co radiation at a dose of 6.0-6.5 Gy and a dose rate of 1.2 Gy/min. Acute radiation sickness has developed in the monkeys causing their death on the 16-20 day. In spite of this, the initial reaction was weakly expressed and according to its manifestation it was impossible to evaluate severity and possible outcome of the lesion. At an early stage of the disease (6-24 hours) insufficient was uranin fluorescence in blood plasma, but more informative were the changes in adhesive properties of leukocytes the dynamics of lymphocytes (lymphopenia), reticulocytes (reticulocytopenia) and shifts in reticulograms (increased per cent of juvenile forms).
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