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  • Title: Synthesis and preliminary pharmacological screening of some 8-substituted methylxanthines.
    Author: Drabczyńska A, Pawłowski M, Gorczyca M, Malec D, Modzelewski J.
    Journal: Pol J Pharmacol Pharm; 1989; 41(4):385-94. PubMed ID: 2634831.
    Abstract:
    Methods of synthesis, chemical properties and results of preliminary pharmacological screening for 8-amino substituted derivatives of caffeine (1-3) and 7,8-disubstituted derivatives of 8-aminotheophylline (8-12) have been described. The compounds show weak sedative and antidepressive activity and some of them (2, 10, 12) also small antinociceptive effect.
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