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  • Title: [Prevalence of non-thyroid autoantibodies in autoimmune dysthyroidies].
    Author: Guerin V, Prestat F, Bene MC, Faure G, Hartemann P, Leclere J.
    Journal: Ann Endocrinol (Paris); 1989; 50(6):477-82. PubMed ID: 2635842.
    Abstract:
    Organ- and non organ-specific autoantibodies can be detected in patients with AITD but large comparative studies have seldom been performed. This study evaluated the prevalence of anti-thyroid, -smooth muscle, -mitochondria, -parietal gastric cells, -salivary duct, -nuclear and -ds DNA autoantibodies assayed by indirect immunofluorescence in 224 patients with Graves' disease or Hashimoto's thyroiditis. Results evidenced a high prevalence of antinuclear antibodies, mostly of non homogenous fluorescence in Graves' (63.1%) and Hashimoto's patients (65.5%), as well as for antisalivary duct antibodies (55.2 and 75%). No positive anti-ds DNA were noticed. No correlation was found between antithyroid antibodies and the others. Different hypothesis could explain this observation which favours a general dysregulation of the autoimmune system.
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