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  • Title: Molecular alterations induced by hypertension in pregnancy on syncythiotrophoblast plasma membranes from human placenta.
    Author: Mazzanti L, Damadei A, Cester N, Benedetti G, Romanini C, Biagini G.
    Journal: Biochem Int; 1989 Dec; 19(6):1373-80. PubMed ID: 2635867.
    Abstract:
    To evaluate the possible functional relationships between hypertensive status and syncythiotrophoblast plasma membrane behaviour we have carried out a freeze-fracturing and biochemical investigation to assess: 1) ultrastructurally, relations between number and diameter of Intramembrane Particles (IMP) and hypertensive conditions; 2) biochemically, actin content of microvilli in this pathological status. Our data in vitro show a decrease of IMP in hypertension before and after Ca++ addition and a decrease of actin in microvilli of hypertensive placenta. These observations seem to be in agreement with the hypothesis of a possible structural immaturity in hypertensive placenta and may represent morphological signs of placental insufficiency.
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