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  • Title: Palladium-Catalyzed Heteroarylation and Concomitant ortho-Alkylation of Aryl Iodides.
    Author: Lei C, Jin X, Zhou JS.
    Journal: Angew Chem Int Ed Engl; 2015 Nov 02; 54(45):13397-400. PubMed ID: 26358935.
    Abstract:
    Three-component couplings were achieved from common aryl halides, alkyl halides, and heteroarenes under palladium and norbornene co-catalysis. The reaction forges hindered aryl-heteroaryl bonds and introduces ortho-alkyl groups to aryl rings. Various heterocycles such as oxazoles, thiazoles and thiophenes underwent efficient coupling. The heteroarenes were deprotonated in situ by bases without the assistance of palladium catalysts.
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