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  • Title: Chemotactic effect of PAF-acether on peritoneal eosinophils from normal rats.
    Author: Martins MA, Etienne A, Soulard C, Domingo MT, Braquet P.
    Journal: Braz J Med Biol Res; 1989; 22(9):1151-4. PubMed ID: 2636011.
    Abstract:
    The chemotactic activity of PAF-acether was compared with that of tetrapeptide eosinophil chemotactic factors of anaphylaxis (ECF-A, Ala-Gly-Ser-Glu and Val-Gly-Ser-Glu) using eosinophils obtained from the peritoneal cavity of normal rats. Cells were isolated by separation over discontinuous metrizamide gradients which resulted in eosinophil suspensions of 80 to 90% purity. PAF-acether produced a dose-dependent effect which, at its maximum, was more than 30-fold greater than control and about 5- to 7-fold greater than the maximal activity obtained with the ECF-A-tetrapeptides. BN 52021 and WEB 2086 inhibited PAF-acether-induced eosinophil chemotaxis in a dose-dependent manner, suggesting that this phenomenon is mediated by specific PAF-acether receptors.
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