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  • Title: [Effect of the composition of the caloric pool on the indicators of protein metabolism in infants].
    Author: Krukowa A, Symonowicz H, Wachnik Z, Koziej M.
    Journal: Probl Med Wieku Rozwoj; 1979; 9():88-106. PubMed ID: 263666.
    Abstract:
    The influences of formula composition (more fat or carbohydrates as a source of energy) upon protein utilization and other indices of protein metabolism was studied. 15 healthy, full-size infants were divided into three groups K,L,M, five infants in every group according, to the formula given to them. The composition of formulas is shown in table I. In the second half of the first year of life all the infants were fed according to schema of infants nutrition obligatory in Poland, based on unmodified cow's milk formulas. In these infants, staying at the Clinical Department from 2 weeks until 12 months, once a month nitrogen balance study was carried out and serum urea nitrogen, serum protein and albumin level, urine urea nitrogen, creatine and hydroxyproline in urine were examined. Results of these studies allow for more exact assessment of diet influence on protein metabolism and body composition. The results of the 3 groups presented in the tables were compared using t-Student's test at the level of significance a = 0,05. In the second half of the first year of life investigations aimed at finding eventual influence of formulas given in he first six month of life on metabolism indices. Intake of protein in infants fed formulas K and L amounted to 2,5 g/kg b.w., but the indices of protein utilization were different. In infants fed the formula in which cow's milk fat was totally replaced by soya oil, digestibility index--Di % was higher, as well as NPU and NBI indices, and serum protein and albumin level. In the second half of the first year of life in those infants nitrogen intake as well as nitrogen absorption were higher, than in infants fed unmodified cow's milk fat formula. Too low content of fat formula (1 g of fat/100 g formula) and high content of protein (3 g/100 g formula) is not profitable in protein utilization and physical development indices. Protein intake in infants of group M was 3,3 g/kg b.w./24 hrs, protein utilization was poorer, serum urea nitrogen was higher, more urine urea nitrogen and total nitrogen in urine was excreted. In these infants, as in group L infants, the quantity of hydroxyproline were lower, which was reflected by poorer indices of physical development. It seems to us, that among three studied formulas formula K had the most profitable influence on the totally investigated infant protein metabolism indices.(ABSTRACT TRUNCATED AT 400 WORDS)
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