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  • Title: [Membranous lesions and histochemical changes in cardiac muscle cells during hypoxia in white rats].
    Author: Obradović D, Mihić N, Aleksić A.
    Journal: Med Pregl; 1989; 42(3-4):121-5. PubMed ID: 2636686.
    Abstract:
    The authors of this paper have explored the effects of intermittent hypoxia on the cell membrane and histochemical changes in the muscle cardiac tissue of the white rat. The animals have been exposed to the experimental conditions characteristic of 7.000 m of height above sea level and divided in three groups. The first one consisted of animals sacrificed immediately after the final exposition (first experimental group), in the second one there were animals sacrificed 24 hours after (the second experimental group), and the third group made animals sacrificed 7 days after the final exposition (the third experimental group). The hypoxial stress elicited the vacuolation in the cardiac muscle fibers of the subendocardial layer of miocard which persisted, and did not reduce its intensity and extensity in all the three groups of animals, while in fuxinorrhagia the intensity and extensity falls to the half of the animals sacrificed 24 hours after the experiment, and completely disappeared in those sacrificed 7 days after the final exposure. Glycogen as well as the activity of succinat-dehydrogenase were preserved in all the three experimental groups of animals. It could be concluded that hypoxia elicites ischemical changes in the sense of vacuolation of muscle tissue which does not disappear or its disappearance is slower than is the case with fuxinorrhagia which leaves a clear evidence, too, that the permeability of cytoplasmatic membrane affected by hypoxia was disturbed.
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