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  • Title: Feedback regulation through myosin II confers robustness on RhoA signalling at E-cadherin junctions.
    Author: Priya R, Gomez GA, Budnar S, Verma S, Cox HL, Hamilton NA, Yap AS.
    Journal: Nat Cell Biol; 2015 Oct; 17(10):1282-93. PubMed ID: 26368311.
    Abstract:
    Actomyosin at the epithelial zonula adherens (ZA) generates junctional tension for tissue integrity and morphogenesis. This requires the RhoA GTPase, which establishes a strikingly stable active zone at the ZA. Mechanisms must then exist to confer robustness on junctional RhoA signalling at the population level. We now identify a feedback network that generates a stable mesoscopic RhoA zone out of dynamic elements. The key is scaffolding of ROCK1 to the ZA by myosin II. ROCK1 protects junctional RhoA by phosphorylating Rnd3 to prevent the cortical recruitment of the Rho suppressor, p190B RhoGAP. Combining predictive modelling and experimentation, we show that this network constitutes a bistable dynamical system that is realized at the population level of the ZA. Thus, stability of the RhoA zone is an emergent consequence of the network of interactions that allow myosin II to feedback to RhoA.
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