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  • Title: Advagraf(®) , a once-daily prolonged release tacrolimus formulation, in kidney transplantation: literature review and guidelines from a panel of experts.
    Author: Caillard S, Moulin B, Buron F, Mariat C, Audard V, Grimbert P, Marquet P.
    Journal: Transpl Int; 2016 Aug; 29(8):860-9. PubMed ID: 26373896.
    Abstract:
    The efficacy and safety of tacrolimus twice-a-day (BID) and once-a-day (QD) formulations are similar. However, the available information regarding the initiation and management of tacrolimus QD is sparse and practical information is lacking. A panel of French experts extensively reviewed the available literature on tacrolimus pharmacokinetics, clinical efficacy, and safety in kidney transplantation and, based on their own day-to-day experience, provided the practitioners with practical guidelines for the daily use and management of tacrolimus QD in de novo initiation or early conversion.
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