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  • Title: Alterations in cortisol concentrations and expression of certain genes associated with neutrophil functions in cows developing retention of fetal membranes.
    Author: Pathak R, Prasad S, Kumaresan A, Kaur M, Manimaran A, Dang AK.
    Journal: Vet Immunol Immunopathol; 2015 Dec 15; 168(3-4):164-8. PubMed ID: 26384698.
    Abstract:
    Elevated cortisol concentrations have been reported to impair the functions and alter the life span of neutrophils in cows. The present study assessed the cortisol concentrations and expression of few genes related to longevity (Fas, Caspase 3, Bcl2) and margination (CD 62L, CD 18/11b) of neutrophils in relation to retention of fetal membranes (RFM) in dairy cows. Cortisol concentrations were significantly higher on the day of calving and day 2 postpartum in RFM cows than normal cows. Expression of CD 62L was significantly lower on the day of calving and day 2 postpartum in RFM cows than normal cows. While expression of Fas and GR was significantly lower on the day of calving, expression of Bcl2 was lower on day 7±2 pre-partum in RFM cows compared to normal cows. No significant difference was observed in the expression of CD 18/11b and Caspase 3 between RFM and normal cows. Cortisol concentration was negatively correlated with expression of GR, Fas, CD 62L, CD18/CD11b and Caspase 3, while positively correlated with immature neutrophil percentage and expression of Bcl2. It may be inferred that cortisol concentrations and expression of certain genes associated with lifespan and margination of neutrophils were altered in cows developing RFM compared to those expelled the fetal membranes normally.
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