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  • Title: Comparison of Kato-Katz thick-smear and McMaster egg counting method for the assessment of drug efficacy against soil-transmitted helminthiasis in school children in Jimma Town, Ethiopia.
    Author: Bekana T, Mekonnen Z, Zeynudin A, Ayana M, Getachew M, Vercruysse J, Levecke B.
    Journal: Trans R Soc Trop Med Hyg; 2015 Oct; 109(10):669-71. PubMed ID: 26385937.
    Abstract:
    BACKGROUND: There is a paucity of studies that compare efficacy of drugs obtained by different diagnostic methods. METHODS: We compared the efficacy of a single oral dose albendazole (400 mg), measured as egg reduction rate, against soil-transmitted helminth infections in 210 school children (Jimma Town, Ethiopia) using both Kato-Katz thick smear and McMaster egg counting method. RESULTS: Our results indicate that differences in sensitivity and faecal egg counts did not imply a significant difference in egg reduction rate estimates. CONCLUSION: The choice of a diagnostic method to assess drug efficacy should not be based on sensitivity and faecal egg counts only.
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