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  • Title: The asymmetric synthesis of polycyclic 3-spirooxindole alkaloids via the cascade reaction of 2-isocyanoethylindoles.
    Author: Zhao X, Liu X, Xiong Q, Mei H, Ma B, Lin L, Feng X.
    Journal: Chem Commun (Camb); 2015 Nov 18; 51(89):16076-9. PubMed ID: 26389723.
    Abstract:
    A highly enantioselective dearomative cascade reaction between 2-isocyanoethylindoles and 3-alkenyl-oxindoles was realized using a chiral N,N'-dioxide-Mg(II) complex catalyst. This reaction provides a straightforward access to polycyclic 3-spirooxindoles bearing cyclopenta[b]indole units with four contiguous stereocenters in excellent yields and moderate to good stereoselectivities via a Michael/Friedel-Crafts/Mannich cascade.
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