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  • Title: Organocatalyzed Asymmetric Synthesis of Axially, Planar, and Helical Chiral Compounds.
    Author: Shirakawa S, Liu S, Kaneko S.
    Journal: Chem Asian J; 2016 Feb 04; 11(3):330-41. PubMed ID: 26395547.
    Abstract:
    Axially, planar, and helical chiral compounds are indispensable building blocks in modern organic synthesis. A wide variety of chiral ligands and catalysts were designed based on these chiral scaffolds, and these chiral ligands and catalysts were used for various catalytic asymmetric transformations to produce important chiral compounds in an optically enriched form. Furthermore, these chiral skeletons are found in the structure of biologically active natural products. Thus, the development of efficient enantioselective methods for the synthesis of these chiral compounds is an important task in the field of organic chemistry. In the last few years, organocatalyzed approaches, which are one of the most reliable catalytic asymmetric methods, became a hot topic. This Focus Review summarizes asymmetric organocatalytic methods for the synthesis of axially, planar, and helical chiral compounds as useful chiral building blocks.
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