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  • Title: Large granular lymphocyte lymphocytosis with neutropenia: a case report.
    Author: Kowalewski J, Pluta A, Modlińska M, Wasik M, Glapiński T, Nowaczyk M, Bozena Adamczyk M, Górski A.
    Journal: Arch Immunol Ther Exp (Warsz); 1989; 37(3-4):481-6. PubMed ID: 2639643.
    Abstract:
    A case of large granular lymphocyte lymphocytosis with neutropenia was studied as evidenced by peripheral lymphocytosis of cells having typical morphology and profound neutropenia. Surface markers analysis revealed that almost all cells were CD8+ and their subpopulation DR+. The cells had strong spontaneous and inducible suppressor functions in vitro. Moreover, their ADCC activity was strong but NK activity very weak.
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